A case of progressive multifocal leukoencephalopathy in an adult patient with ADA-SCID.

A case of progressive multifocal leukoencephalopathy in an adult patient with ADA-SCID.

Shin H, Broderick L, Azevedo J, Mulligan C, Hird K, Goodwill V, Parkin C, Mortensen S, Traveller M, Rayes A, Bohnsack J, Kohn DB, Tarrant TK, Hershfield M, Lyons JJ. J Hum Immun. 2026 Jul 21;2(5):e20250093. doi: 10.70962/jhi.20250093. eCollection 2026 Sep 7. PMID: 42483435

Publication Abstract

This case report describes progressive multifocal leukoencephalopathy in a patient with ADA-SCID status after gene therapy. Persistent metabolic dysfunction likely contributed to JC virus reactivation, highlighting this rare complication of ADA-SCID and incomplete reconstitution seen with early protocols.